Physiology and Functional Genomics: Polycystic Kidney Disease

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In this activity, you will independently on your own explore the Physiology and Functional Genomics as it relatesto Polycystic Kideny Disease.

Objectives: 
1. Learn to use literature searches. 
2. Understand the complexity and physiological basis of diseases of genetic origin. 
3. Explore and understand accepted treatment options.
 Procedure: You will write a short (no more than 1000 words total) addressing each of the following. Each ofthese questions can be addressed sufficiently in one paragraph (250 words or less for each question). 
1) What is the genetic basis of the disease? 
2) What is the molecular basis of the disease? (what is abnormal at the cellular, biochemical, or molecularlevel?) 
3) What are the physiologic implications of the disease? (what is abnormal about the physiology of people withthis disease?)4) What are the treatment options? 
Requirements 
An important objective of this exercise is to find reliable information that is pertinent to your needs. You couldstart with standard textbooks, such as Harrisons Textbook of Medicine, Ganongs Review of Medical Physiology.However, one disadvantage of relying solely on this approach is that textbooks are rarely current. After gatheringgeneral information, consult reliable information online. There are several sites which exist for the purpose ofteaching, beyond merely Wikipedia. For example, see http://www.ncbi.nlm.nih.gov/disease. Another excellentresource is PubMed, the national repository of all peer-reviewed medical literature. In PubMed, you will be ableto find both primary literature and reviews which will be useful. This site is accessed through the National Libraryof Medicine, and can be found at: http://www.ncbi.nlm.nih.gov/pubmed.

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